Here it is then, our guide to the biggest slot game wins ever claimed in land-based casinos: 6. In fact one particular slot machine – Megabucks – has been responsible for every single winner on our list. Thanks to progressive jackpots, slot games have provided some of the biggest casino wins in history. Yet that could not be further from the truth. Assuming they are low stakes and thus provide low wins, many ignore them for high-paying table games like blackjack and poker. Slot games can often be overlooked by hardcore casino aficionados.